Clinical Evaluation of Acanthosis Nigricans and Its Correlation with Endocrine, Metabolic and Nutritional Factors in Gujarat,India

Acanthosis nigricans (AN) refers to the velvety, black hyperpigmentation in flexures usually on neck and axillae. AN is associated with multiple endocrinopathies insulin resistance reported be a common denominator among them. The aim of study was identify correlation metabolic factors (Serum glucose, lipid profile), endocrine (TSH, serum insulin), nutritional (vitamin B12, Ferritin) patients Aravalli district Gujarat state. A total Seventeen Patients (11 male 6 female) were included History, clinical observations, physical parameters, biochemical tests noted some likely explored. age 28.41±15.09 years for group 35.45±8.74 control group. mean BMI found higher at 1 % level significance (P = 0.007) implying that overweight/obesity AN. TSH value than 5 0.0115) hypothyroidism (elevated value) 45.45 had blood glucose levels insulin. profile, vitamin B12 ferritin non-significance level. All statistical performed using graph pad prism software (version 5.0). Positive correlations observed between fasting hyperinsulinemia others such as like overweight/obesity, hypothyroidism, This implies can serve marker detecting hypothyroidism. Some parameters like, Serum could not correlated Thus, targeted lifestyle behavioral modifications an early stage avoid serious consequences